Metabolic N-Hydroxylation. Use of Substituent Variation to Modulate the in Vitro Bioactivation of 4-Acetamidostilbenes

DOI: 10.1021/jm00183a014

Source and publish data:

Journal of Medicinal Chemistry p. 1038 - 1044 (1980)

Update date:2022-08-04

Topics:

Authors:

Hanna, Patrick E.

Gammans, Richard E.

Sehon, Russell D.

Lee, Man-Kil

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00183a014

N-Hydroxylation is an obligate step in the bioactivation of carcinogenic aryl amides.Previous reports from this laboratory demonstrated that variation of the 4' substituent of trans-4-acetamidostilbene (1) has a marked effect on the rate of its in vitro m

Full text of DOI:10.1021/jm00183a014

Products guided by the article

Product name:4-Trifluormethyl-4'-aminostilben

Cas No:74519-00-9

R&D Labs maybe for 74519-00-9

Jiaxing Carry Bio-Chem Technology Co.,Ltd

website:http://www.carrybiotech.com

Contact:0573-82788958

Address:Add.Fl 3th, Pharm Vally,Kaichuang Rd, Xiuzhou District, Jiaxing, Zhejiang,314031,China
NEW FORTUNE INDUSTRIAL CO.,LTD.

website:http://newfortune.lookchem.com/

Contact:+86-25-8645-9456

Address:C4-105 GREEN ISLAND FLOWER TOWN
Changzhou Sunlight Pharmaceutical Co., Ltd.

Contact:+86-519-83131668;83139028;83138042;83137041

Address:JiuliStreet, Benniu Town Changzhou City, Jiangsu Province
AUSHUN PHARMACEUTICAL TECHNOLOGY CO,.LTD

Contact:+86-25-86883560 15951806178

Address:14 Dayingbi, Zhujiang Rd. East, Nanjing, Jiangsu, China.
Nanjing Chemzam Pharmtech Co., Ltd.

Contact:+86-25-86462165,+86-13915979898

Address:C5-1，6 Maiyue Road，Maigaoqiao，Nanjing，Jiangsu，China

Relevant to this article

Doi:10.1021/jo01170a015
(1947)
Selective tetratosylation of sucrose: isolation of the 2,6,1',6'-tetrasulphonate

Doi:10.1016/S0008-6215(00)85374-4
(1980)
Studies on the metabolites of fluorescein in rabbit and human urine.

Doi:10.1248/cpb.28.1403
(1980)
Synthesis of p-trifluoroacetamidophenyl O-α-D-galactopyranosyl-(1<*>2)-O-α-D-mannopyranosyl-(1<*>4)-α-L-rhamnopyranoside

Doi:10.1016/S0008-6215(00)85378-1
(1980)
Synthesis, properties, and reactivity with carbon dioxide of (allyl) ₂Ni(L) complexes

Doi:10.1021/om2002238
(2011)
Doi:10.1021/ja01863a076
(1940)

Article Doi