Metabolic N-Hydroxylation. Use of Substituent Variation to Modulate the in Vitro Bioactivation of 4-Acetamidostilbenes

DOI: 10.1021/jm00183a014

Source and publish data:

Journal of Medicinal Chemistry p. 1038 - 1044 (1980)

Update date:2022-08-04

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Authors:

Hanna, Patrick E.

Gammans, Richard E.

Sehon, Russell D.

Lee, Man-Kil

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Article abstract of DOI:10.1021/jm00183a014

N-Hydroxylation is an obligate step in the bioactivation of carcinogenic aryl amides.Previous reports from this laboratory demonstrated that variation of the 4' substituent of trans-4-acetamidostilbene (1) has a marked effect on the rate of its in vitro m

Full text of DOI:10.1021/jm00183a014

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