European Journal of Organic Chemistry p. 2035 - 2038 (2008)
Update date:2022-08-04
Topics:
Carreno, M. Carmen
Hernandez-Torres, Gloria
Urbano, Antonio
Colobert, Francoise
A homochiral sulfoxide-directed reductive deoxygenation of 2-(p-tolylsulfinyl)methyl-2-chromanols allows the stereoselective formation of 2H-chromans with up to 95:5 diastereoisomeric ratio. This new methodology was applied in a short and convergent enantioselective synthesis of the (S,R,R,R)-enantiomer of the antihypertensive drug Nebivolol. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
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