Practical synthesis of 5-Fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a key intermediate in the preparation of potent deoxycytidine kinase inhibitors

DOI: 10.1021/op900060u

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Organic process research and development p. 807 - 811 (2009)

Update date:2022-08-03

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Authors:

Wenxue, Wu

Keyes, Philip

Haiming, Zhang

Jie, Yan

Kanamarlapudi, Ramanaiah C.

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Article abstract of DOI:10.1021/op900060u

A practical synthesis of 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a key intermediate in the preparation of a new class of potent deoxycytidine kinase (dCK) inhibitors, is described. The commercially available 2,4-dichloro-5-fluoropyrimidine (12) i

Full text of DOI:10.1021/op900060u

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