Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization

DOI: 10.1016/j.ejmech.2017.02.047

Source and publish data:

European Journal of Medicinal Chemistry p. 209 - 222 (2017)

Update date:2022-07-30

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Authors:

Zhang, Heng

Tian, Ye

Kang, Dongwei

Huo, Zhipeng

Zhou, Zhongxia

Liu, Huiqing

De Clercq, Erik

Pannecouque, Christophe

Zhan, Peng

Liu, Xinyong

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Article abstract of DOI:10.1016/j.ejmech.2017.02.047

A novel series of uracil-bearing DAPYs derivatives were designed and synthesized via structure-based molecular hybridization to discover compounds with improved anti-resistance profiles. Anti-HIV activity of the designed compounds was tested in MT-4 cell

Full text of DOI:10.1016/j.ejmech.2017.02.047

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