Synthesis of 7-Substituted 5,6-Dimethyl-2,4-dioxo-1,2,4,7-tetrahydropyrrolooxazines

Article abstract of DOI:10.1055/s-1985-31355

The title compounds 2 are prepared by the cyclization of substituted pyrroles 3 with phosgene in refluxing tetrahydrofuran.In the case of 3a, it is shown that the cyclization can also be achieved after alkylation to give 8.