Bioorganic and Medicinal Chemistry Letters p. 101 - 106 (1998)
Update date:2022-08-03
Topics:
Kiuchi, Masatoshi
Adachi, Kunitomo
Kohara, Toshiyuki
Teshima, Koji
Masubuchi, Yumi
Mishina, Tadashi
Fujita, Tetsuro
Desymmerization of symmetric FTY720 by substitution of different alkyl groups for one of the prochiral hydroxymethyl groups was performed. The size of the alkyl groups and the absolute configuration at quaternary carbon were important on immunosuppressive activity.
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