APPLICATION DE REACTIONS D ' HYDROALUMINATION EN SYNTHESE ORGANIQUE: OBTENTION D' α-ALKYL-α-HYDROXYESTERS PAR ADDITION ENANTIOSELECTIVE DE TETRAALKYLALUMINATES AU PHENYLGLYOXALATE DE (-)-MENTHYLE

Article abstract of DOI:10.1016/S0040-4039(00)98985-8

Using tetraalkylaluminates prepared via hydroalumination in THF of various vinyl compounds resulted in selective addition to the keto group of phenylglyoxylic acid (-)-menthyl ester.Not only simple alkyl groups but also functionalized alkyl groups were added.By this way, a variety of α-substituted mandelic acid (-)-menthyl esters were obtained with diastereomeric excesses close to 70percent.