ASYMMETRIC MICHAEL REACTION OF α-ALKYL β-KETO ESTERS VIA CHIRAL ENAMINES

DOI: 10.1016/S0040-4039(00)84081-2

Source and publish data:

Tetrahedron Letters p. 715 - 716 (1986)

Update date:2022-08-03

Topics:

Authors:

Tomioka, Kiyoshi

Ando, Kaori

Yasuda, Kosuke

Koga, Kenji

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Article abstract of DOI:10.1016/S0040-4039(00)84081-2

Depending on the combination of solvents and additives, Michael reaction of chiral lithioenamines generated from 1a,b with di-tert-butyl methylenemalonate (2) affords, after hydrolysis, either enantiomers of α,α-disubstituted β-keto esters (3,4) in high enantiomeric excess.

Full text of DOI:10.1016/S0040-4039(00)84081-2

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