
Tetrahedron Letters p. 715 - 716 (1986)
Update date:2022-08-03
Topics:
Tomioka, Kiyoshi
Ando, Kaori
Yasuda, Kosuke
Koga, Kenji
Depending on the combination of solvents and additives, Michael reaction of chiral lithioenamines generated from 1a,b with di-tert-butyl methylenemalonate (2) affords, after hydrolysis, either enantiomers of α,α-disubstituted β-keto esters (3,4) in high enantiomeric excess.
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