A New Synthesis of Indoles by Electrocyclic Ring Closure of Dialkenylpyrroles. Synthesis of Alkenylpyrroles from 1-Tosylalkenyl Isocyanides and Michael Acceptors

Article abstract of DOI:10.1021/jo00372a006

Addition of allylic anions derived from 1-tosylalk-1-enyl isocyanides 1 to Michael acceptors, in combination with ring closure to the isocyano carbon, provides a highly efficient synthesis of 2-alk-1'-enylpyrroles (types A-C).A proper selection of Michael