WITTIG REARRANGEMENT-BASED APPROACHES TO STEREOCONTROL OVER THREE CONTIGUOUS CHIRAL CENTERS. NEW ENTRIES TO THE (+/-)-PRELOG-DJERASSI LACTONE

Article abstract of DOI:10.1246/cl.1985.1725

Three <2,3>Wittig-based approaches for stereocontrol over three contiguous chiral centers are described within the synthesis of the title lactone.In these methods, the erythro-selective <2,3>Wittig variants are combined with one of the stereoselective processes: the Michael addition, the radical cyclization, and the hydroboration.