USE OF 2-(2-PYRIDYL)ETHYL GROUP AS A NEW PROTECTING GROUP OF INTERNUCLEOTIDIC PHOSPHATES IN OLIGONUCLEOTIDE SYNTHESIS

DOI: 10.1246/cl.1986.699

Source and publish data:

Chemistry Letters p. 699 - 702 (1986)

Update date:2022-08-04

Topics:

Authors:

Takaku, Hiroshi

Hamamoto, Shoji

Watanabe, Testuo

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Article abstract of DOI:10.1246/cl.1986.699

2-(2-Pyridyl)ethyl group is used as a highly selective protecting group of internucleotidic phosphates that is removable under mild conditions by treatment with CH3I in CH3CN without a side reaction such as N-alkylation.

Full text of DOI:10.1246/cl.1986.699

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