Journal of Organometallic Chemistry p. 157 - 168 (1988)
Update date:2022-07-29
Topics:
Alami, N. El.
Belaud, C.
Villieras, J.
The organozinc derivative (2a) of ethyl α-bromomethyl acrylate is not nucleophilic towards haloalkanes but can be alkylated with chlorotrimethylsilane. 2a is unreactive towards carbon-oxygen single bonds and is unsuitable for conjugate addition (α-enones and α,β-ethylenic esters).Its acylation can be carried out in DME in the presence of palladium(0) catalyst.Reactions with carbon-oxygen and and carbon-nitrogen double bonds permit the preparation of α-methylene γ-butyrolactones and lactams without the formation of side-products.This route is especially suitable for reactions with substrates such as imines that are both nucle ophilic and electrophilic.
View MoreHebei Tianxiang Biological & Pharmaceutical Co., Ltd
Contact:86-0312-6615158
Address:No 42 fazhan street qingyuan county
RongCheng Tianyu Technology Co.,Ltd.
Contact:86-631-7519595
Address:220Ping Donghai Road RongChengCity,ShangDong Province China
Contact:86-25-84683399
Address:605, Phoenix Herui Plaza, No.389, South Taiping Road, Nanjing, China 210002
Beijing Harmony Chemical Co., Ltd.
Contact:86-010-84956928
Address:Room 207, Jin feng he B building, No 8 Xin Jie Kou Wai Street, Xi Cheng District, Beijing,PRC. 10008
Kaymossy BioChem Tech Co., Ltd
website:http://www.kaimosi.com
Contact:0571-87191913/0571-87199097
Address:Room 215, Building 3rd, No.288 Ningxia Road, Qingdao city, China
Doi:10.1039/jr9400000676
(1940)Doi:10.1016/j.bmcl.2009.11.125
(2010)Doi:10.1016/j.bmcl.2008.06.031
(2008)Doi:10.1021/tx010131t
(2002)Doi:10.1021/jo00963a005
(1973)Doi:10.1021/jo00265a025
(1989)