Journal of Medicinal Chemistry p. 168 - 173 (1987)
Update date:2022-07-30
Topics:
Sami, Salah M.
Iyengar, Bhashyam S.
Remers, William A.
Bradner, William T.
A series of 26 mitomycin A analogues including 23 new ones was prepared by a variety of methods.The most useful methods were alkoxide exchange on mitomycin A and treatment of 7-hydroxymitosane with 3-substituted 1-phenyltriazenes.Many of the new analogues were superior to mitomycin C in the P388 leukemia assay and the more stringent subcutaneous B16 melanoma assay both in mice.Four of them gave long-term survivors in the latter assay.Quantitative correlations between log P and antitumor activity were not possible, but some guidelines for future analogue development are proposed.
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