The Synthesis of N,N'-O-Trisubstituted Hydroxylamines via a Mild Reductive Alkylation Procedure: An Improved Synthesis of the MMI Backbone

Article abstract of DOI:10.1055/s-1997-5773

A mild procedure for the synthesis of N,N'-O-trisubstituted hydroxylamines via the reductive alkylation of N,O-disubstituted hydroxylamines with both aldehydes and ketones has been developed. We have applied this reaction to the synthesis of methylene (methylimino) (MMI) linked dimeric nucleosides, which are of potential use in antisense applications.