SOLID PHASE SYNTHESIS OF PEPTIDE AMINOALKYLAMIDES DEVELOPMENT AND APPLICATION OF NEW LINKING AGENTS

DOI: 10.1016/S0040-4039(00)96803-5

Source and publish data:

Tetrahedron Letters p. 5647 - 5650 (1987)

Update date:2022-09-26

Topics: Yield Cleavage Mass spectrometry (MS) Deprotection HPLC (high-performance liquid chromatography) Scale-up Coupling Reaction Purity Resin Solid phase synthesis Activating reagents Fmoc (Fluorenylmethyloxycarbonyl) TFA (Trifluoroacetic Acid) Lyophilization (Freeze-Drying) Boc (tert-Butyloxycarbonyl)

Authors:

Breipohl, G.

Knolle, J.

Geiger, R.

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Article abstract of DOI:10.1016/S0040-4039(00)96803-5

A new method for the preparation of peptide aminoalkylamides by solid phase synthesis using a modified Fmoc strategy is described.Key step is the synthesis of compound 6 as acid labile linker.

Full text of DOI:10.1016/S0040-4039(00)96803-5

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