Journal of Medicinal Chemistry p. 2092 - 2097 (1988)
Update date:2022-08-05
Topics:
Shinkai, Hisashi
Toi, Koji
Kumashiro, Izumi
Seto, Yoshiko
Fukuma, Mariko
et al.
N-Benzoyl-DL-phenylalanine (1) was found to possess hypoglycemic activity.A series of the analogues of compound 1 were prepared and evaluated for their blood glucose lowering activity.Both the steric effects of the phenylalanine moiety and the effects of variations in the acyl moiety were investigated.This study elucidated some of the structure-activity relationships and led to the development of N-(4-ethylbenzoyl)-D-phenylalanine (34), which was 50 times more potent than the initial compound 1.
View MoreContact:+86-(0)21-3770 9035
Address:Room 301, Building 2, Meijiabang Road 1508, Shanghai China
Contact:+86-515-88356562
Address:No.2, West Daqing Road, Yancheng, Jiangsu, China
Shanghai Hanshare Industry Co.,Ltd.
Contact:86 21 20960688
Address:RM902-903,Building E, Wanda Plaza,No.26,Zhoukang Road, Pudong District, Shanghai, China
Contact:0572-2722882
Address:1201,F3,xinghuibandao,
Hangzhou Bayee Chemical Co.,Ltd.
Contact:+86-571-86990109
Address:No.380, Jiangnan Auenue, Binjiang District, Hangzhou, China
Doi:10.1002/jhet.5570300140
(1993)Doi:10.2174/157017810791514733
(2010)Doi:10.1002/ejoc.200800345
(2008)Doi:10.1021/jm8006933
(2008)Doi:10.1002/cmdc.202100344
(2021)Doi:10.1021/jo01059a049
(1962)
