ASYMMETRIC HYDROGENATION CATALYZED BY RHODIUM COMPLEXES OF 2,3-BIS(DIMENTHYLPHOSPHINO)MALEIC ANHYDRIDE AND 2,3-BIS(DIMENTHYLPHOSPHINO)-N-PHENYLMALEIMIDE

Article abstract of DOI:10.1016/0022-328X(86)80090-0

2,3-Bis(dimenthylphosphino)maleic anhydride and the phenylimide derivative have been prepared from 2,3-dichloromaleic anhydride and 2,3-dichloro-N-phenylmaleimide, respectively, and dimenthyl(trimethylsilyl)phosphine.These compounds have been used as ligands for Rh complexes and have been tested in the asymmetric hydrogenation of α-acetamidocinnamic acid, methyl-α-acetamidocinnamate and itaconic acid.Optical yields of up to approximately 70percent were obtained with α-acetamidocinnamic acid.