Studies directed towards the synthesis of immunosuppressive agent FK-506: Construction of the tricarbonyl moiety

DOI: 10.1016/S0040-4039(00)88827-9

Source and publish data:

Tetrahedron Letters p. 1439 - 1442 (1990)

Update date:2022-07-29

Topics:

Authors:

Rao Rao

Chakraborty

Reddy Reddy

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Article abstract of DOI:10.1016/S0040-4039(00)88827-9

Alkylation of a suitably functionalised dithiane precursor with L-N-(α-haloacetyl)-pipecolic acid methyl ester, followed by oxidation of the active methylene group provided an easy route to 1,2,3-tricarbonyl functionality of FK-506.

Full text of DOI:10.1016/S0040-4039(00)88827-9

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