Studies directed towards the synthesis of immunosuppressive agent FK-506: Construction of the tricarbonyl moiety

DOI: 10.1016/S0040-4039(00)88827-9

Source and publish data:

Tetrahedron Letters p. 1439 - 1442 (1990)

Update date:2022-07-29

Topics:

Authors:

Rao Rao

Chakraborty

Reddy Reddy

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)88827-9

Alkylation of a suitably functionalised dithiane precursor with L-N-(α-haloacetyl)-pipecolic acid methyl ester, followed by oxidation of the active methylene group provided an easy route to 1,2,3-tricarbonyl functionality of FK-506.

Full text of DOI:10.1016/S0040-4039(00)88827-9

Products guided by the article

Product name:(2R,4aR,6S,7R,8aS)-6-Methoxy-7-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine

Cas No:105930-42-5

R&D Labs maybe for 105930-42-5

Nanjing Ruizhi Industry & Technologh Co.，Ltd.

Contact:+86-25-86808110

Address:441-4-A5,NO.12 Longzang Avenue,Yuhuatai District,210039,Nanjing
Shanghai Topchem Co., LTD

website:http://www.shtopchem.com/

Contact:0086-0576-87776998

Address:room no 1608,xuhui business building yude road,xujiahui street, xuhui district
Laohekou Jinghong Chemical Co.,Ltd

Contact:+86-0710-3702747

Address:163.East，Huagong Road，Laohekou
Sinochem Jiangsu Co.,Ltd.

Contact:86-25-51817806

Address:No. 216, middle longpan road, jincheng tower, floor 21-22, nanjing ,china
MiHecb Bio-Tech Co., Ltd.

Contact:+86-0592 5353131

Address:No.56 Guani Road Software Park 2,Siming District

Relevant to this article

(4-(Bis(4-Fluorophenyl)Methyl)Piperazin-1-yl)(Cyclohexyl) methanone hydrochloride (LDK1229): A new cannabinoid CB1 receptor inverse agonist from the class of benzhydryl piperazine analogs

Doi:10.1124/mol.114.095471
(2015)
The in situ Generation of Thiazyl Trichloride: A Synthon for C-N-S Heterocycles

Doi:10.1039/c39870001889
(1987)
Synthesis of reaction-ready 6,6′-biindole and 6,6′-biisatin via palladium(ii)-catalysed intramolecular C-H functionalisation

Doi:10.1039/c002098b
(2010)
Ruthenium-catalyzed rearrangement of cis-1-ethynyl-2-vinyloxiranes to substituted phenols

Doi:10.1055/s-2006-926255
(2006)
Secondary structure in glycosaminoglycuronans: N.M.R. spectra in dimethyl sulphoxide of disaccharides related to hyaluronic acid and chondroitin sulphate.

Doi:10.1016/S0008-6215(00)80969-6
(1982)
Bis- and tris-phosphinostannane gold complexes featuring Au → Sn dative interactions: Synthesis, structures, and DFT calculations

Doi:10.1016/j.poly.2016.07.010
(2017)

Article Doi