Anthracyclinones. 3. Chiral Pool Synthesis of Anthracyclinones via Tetralin Intermediates

Article abstract of DOI:10.1021/jo00382a016

The synthesis of AB ring segments 14, 15, and 28 of anthracyclinones involves in a key step an ortho-alkylation of bromodimethoxybenzene 5 (X = Br) with chiral aldehydes 6 or 19, which are themselves prepared from the isopropylidene derivative of α-D-isos