Improved synthetic routes to the novel thromboxane receptor antagonist ICI 192605: Activity of synthetic 1.3-dioxane intermediates

Article abstract of DOI:10.1111/j.2042-7158.1990.tb05349.x

A study of the synthetic routes to the thromboxane receptor antagonist ICI 192605 4(Z)-6-(2-o-chlorophenyl-4- o-hydroxyphenyl- 1,3-dioxan-cis-5-yl) hexenoic acid is described which led to an improvement in overall synthetic yield from 20 to 55%. In-vitro