Asymmetric Reduction of Phosphinyl Imines with Hydride Reagents. Enantioselective Synthesis of Chiral Primary Amines

Article abstract of DOI:10.1021/jo00380a047

Prochiral diphenylphosphinyl imines are asymmetrically reduced by chiral hydride reagents to chiral diphenylphosphinylamines.For dialkyl examples, the enantioselectivities obtained are the highest thus far for hydride reductions of imine derivatives.