Asymmetric Reduction of Phosphinyl Imines with Hydride Reagents. Enantioselective Synthesis of Chiral Primary Amines

DOI: 10.1021/jo00380a047

Source and publish data:

Journal of Organic Chemistry p. 702 - 704 (1987)

Update date:2022-08-04

Topics:

Authors:

Hutchins, Robert O.

Abdel-Magid, Ahmed

Stercho, Yuriy P.

Wambsgans, Anthony

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Article abstract of DOI:10.1021/jo00380a047

Prochiral diphenylphosphinyl imines are asymmetrically reduced by chiral hydride reagents to chiral diphenylphosphinylamines.For dialkyl examples, the enantioselectivities obtained are the highest thus far for hydride reductions of imine derivatives.

Full text of DOI:10.1021/jo00380a047

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