Tetrahedron p. 39 - 45 (2017)
Update date:2022-07-30
Topics: Hydroxylation Preparation Chirality Enzyme Enzymatic desymmertization (2R, 3R, 4R)-3-hydroxy-2,4,6-trimethylheptanoic acid Trimethylheptanoic acid
Tokairin, Yoshinori
Konno, Hiroyuki
Synthesis of a unique fatty acyl unit to build the N-terminus of callipeltin A and homophymine B is described. Our approach to access (2R, 3R, 4R)-3-hydroxy-2,4,6-trimethylheptanoic acid uses enzymatic hydrolysis for the desymmetrization of achiral acetate, followed by diastereoselective Roush crotylboration and Wittig olefination for the backbone construction.
View MoreSHANDONG ZHANHUA YONGHAO PHARMACEUTICAL TECH.CO.,LTD
Contact:+86-576-88685096
Address:GENGJU VILLAGE NORTH ONE KILOMETER,ZHANHUA DISTRICT,BINZHOU CITY,SHANDONG PROVINCE,CHINA.
Chongqing KonAo Health Co.,Ltd
Contact:13687578375
Address:wuhan hubei china
Dezhou Longteng Chemical Co., Ltd.
website:http://www.sodium-methoxide.cn/
Contact:0086-18866052283
Address:Xinhua Industrial Zone, Dezhou City, Shandong Province, China
Contact:+86-158-05817090
Address:ROOM 9F, FLAT 2, GUODU DEVELOPING BLDG, No.182, ZHAOHUI ROAD
MTT Pharma & Bio-technology Co.,Ltd
Contact:+86-21-58407925
Address:Room2019, Building C, Tomson Center, No.158, Zhang Yang Road, Shanghai, China
Doi:10.1021/jm00387a003
(1987)Doi:10.1246/bcsj.56.349
(1983)Doi:10.1016/j.tet.2008.05.078
(2008)Doi:10.1016/j.mencom.2007.09.019
(2007)Doi:10.1080/10426500701796249
(2008)Doi:10.1021/ol801607r
(2008)