An improved synthesis of (-)-dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan via ozonolysis of (-)-sclareol

Article abstract of DOI:10.1016/0040-4039(94)88497-8

Ozonolysis of (-)-sclareol 1 under a wide range of experimental conditions has been investigated. The addition of one of the following; sodium periodate, sodium iodate, iodine or potassium iodide affords after workup the methyl-ketone 2 in excellent yield. Further elaboration of 2 afforded the title compound 4 in high yield.