Structure-activity relationships of cyclic opioid peptide analogues containing a phenylalanine residue in the 3-position

Article abstract of DOI:10.1021/jm00394a027

Ten analogues of the highly μ-receptor selective cyclic opioid peptide H-Tyr-D-Orn-Phe-Asp-NH₂ (1) were synthesized by the solid-phase method and were characterized in vitro in μ- and δ-receptor representative binding assays and bioassays. Thes