A New Protocol for the Diastereoselective Formation of Lactones from either Achiral or Chiral Vinylogous Urethanes

DOI: 10.1021/jo00380a050

Source and publish data:

Journal of Organic Chemistry p. 708 - 710 (1987)

Update date:2022-08-05

Topics:

Authors:

Schlessinger, Richard

Tata, James R.

Springer, James P.

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Article abstract of DOI:10.1021/jo00380a050

The condensations of vinylogous urethanes, with or without a chiral auxiliary, and a variety of acid chlorides are described.Treatment of these acylated products with either L-Selectride or organometallic reagents leads, with high diastereoselectivity, to lactone products.

Full text of DOI:10.1021/jo00380a050

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