Lithiation of 2-Aminoquinoline Derivatives: Functionalization at the 3-Position

DOI: 10.1055/s-1986-31744

Source and publish data:

Synthesis p. 670 - 672 (1986)

Update date:2022-08-03

Topics:

Authors:

Jacquelin, J. M.

Marsais, F.

Godard, A.

Queguiner, G.

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Article abstract of DOI:10.1055/s-1986-31744

2-Pivaloylaminoquinoline (2) undergoes o-lithiation with n-butyllithium to give the intermediate lithio derivative 3.Reaction of 3 with various electrophiles affords 3-substituted 2-pivaloylaminoquinolines 4.

Full text of DOI:10.1055/s-1986-31744

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