Bioorganic and Medicinal Chemistry p. 5079 - 5098 (2018)
Update date:2022-07-29
Topics:
Shinozuka, Tsuyoshi
Tsukada, Tomoharu
Fujii, Kunihiko
Tokumaru, Eri
Shimada, Kousei
Onishi, Yoshiyuki
Matsui, Yumi
Wakimoto, Satoko
Kuroha, Masanori
Ogata, Tsuneaki
Araki, Kazushi
Ohsumi, Jun
Sawamura, Ryoko
Watanabe, Nobuaki
Yamamoto, Hideki
Fujimoto, Kazunori
Tani, Yoshiro
Mori, Makoto
Tanaka, Jun
The lead identification of a novel potent selective PPARγ agonist, DS-6930 is reported. To avoid PPARγ-related adverse effects, a partial agonist was designed to prevent the direct interaction with helix 12 of PPARγ-LBD. Because the TZD group is known to
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