Heterocycles p. 2243 - 2250 (2008)
Update date:2022-07-30
Topics:
Khettache, Nawel
Berredjem, Malika
Regainia, Zine
Aouf, Nour-Eddine
New sulfa-heterocyclic containing aziridine moiety derivatives such as 3-benzyl-2-thia-1,3-diazabicyclo[3.1.0]hexane 2,2-dioxide has been obtained starting from 2-benzyl-4-chloromethyl-1,2,5-thiadiazolidine 1,1-dioxide in alkaline conditions. The aziridine moiety was opened by various nucleophiles to give vicinal diamines which used as an intermediate in the preparation of other bicyclic compounds with orthogonal protections such as 2,5-dibenzyl-1,2,5- thiadiazolo[2,3-a]pyrazine 1,1-dioxide in good yield. The Japan Institute of Heterocyclic Chemistry.
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