Quinazolin-2-ones having a spirohydantoin ring. III. A general and efficient synthesis of 3'-substituted spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones

DOI: 10.1248/cpb.39.1694

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1694 - 1698 (1991)

Update date:2022-07-29

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Authors:

Yamagishi

Ozaki Ozaki

Yamada Yamada

Da-Te Da-Te

Okamura Okamura

Suzuki Suzuki

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Article abstract of DOI:10.1248/cpb.39.1694

The reaction of 1-carbamoylisatins 2 with 2-ethyl-2-isothiourea hydrobromide in the presence of triethylamine followed by acid-catalyzed cyclization of the resulting 4-(2-ethyl-2-isothioureido)carbonyl-3,4-dihydro-4-hydroxy-2(1H)- quinazolinones provides

Full text of DOI:10.1248/cpb.39.1694

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