Synthesis and in vitro LTD4 antagonist activity of bicyclic and monocyclic cyclopentylurethane and cyclopentylacetamide N-arylsulfonyl amides

DOI: 10.1021/jm00171a043

Source and publish data:

Journal of Medicinal Chemistry p. 2621 - 2629 (1990)

Update date:2022-07-29

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Authors:

Matassa Matassa

Brown Brown

Bernstein

Shapiro Shapiro

Maduskuie Jr.

Cronk Cronk

Vacek Vacek

Yee Yee

Snyder Snyder

Krell Krell

Lerman Lerman

Maloney Maloney

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Article abstract of DOI:10.1021/jm00171a043

The dissociation constants (K(B)) at the LTD₄ receptor on guinea pig trachea of a series of monocyclic and bicyclic cyclopentylurathane and cyclopentylacetamide N-arylsulfonyl amides have been measured. The K(B) was found to be remarkably toler

Full text of DOI:10.1021/jm00171a043

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