
Chemistry of Heterocyclic Compounds p. 532 - 538 (1986)
Update date:2022-08-05
Topics:
Chernyshova, N. B.
Shibaev, V. N.
The ambident anion of 1-methyluracil gives with phenylbenzhydrazonoyl chloride, depending on the conditions, the N-acylation product (polar solvent, room temperature), or the O-acylation product (nonpolar solvent, heating), which rearranges to a cytosine derivative.Convenient methods have been developed for the preparation of 6-methyl-1,3-diphenyl-5,6-dihydro-5-oxopyrimido<4,3-c>triazolium chloride, a fluorescent derivative of 1-methyluracil, from the N-acylation product, and for the rapid base cleavage of the uracil ring under very mild conditions.
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(1968)