Cardiotonic Agents. 2. (Imidazolyl)aroylimidazolones, Highly Potent and Selective Positive Inotropic Agents

DOI: 10.1021/jm00391a013

Source and publish data:

Journal of Medicinal Chemistry p. 1342 - 1347 (1987)

Update date:2022-08-03

Topics:

Authors:

Hagedorn, Alfred A.

Erhardt, Paul W.

Lumma, William C.

Wohl, Ronald, A.

Cantor, Elinor

et al. et al.

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Article abstract of DOI:10.1021/jm00391a013

A series of 4-alkyl-1,3-dihydro-5-<(1H-imidazolyl)benzoyl>-2H-imidazol-2-ones 9 was synthesized and evaluated in vitro for positive inotropic and cyclic AMP phosphodiesterase inhibitory activity.A wide range of inotropic and enzyme-inhibitory potencies wa

Full text of DOI:10.1021/jm00391a013

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