Potent Prostacyclin Analogues Based on the Bicyclooctane Ring System

DOI: 10.1021/jo00389a038

Source and publish data:

Journal of Organic Chemistry p. 2860 - 2868 (1987)

Update date:2022-08-03

Topics:

Authors:

Kluge, Arthur F.

Kertesz, Denis J.

O-Yang, Counde

Wu, Helen Y.

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Article abstract of DOI:10.1021/jo00389a038

The novel and biologically active prostacyclin mimetics 2 and 29 were prepared in a sequence based on the regioselective opening of epoxide 7 with a lithium acetylide in the presence of boron trifluoride etherate.The regioselectivity of epoxide opening wa

Full text of DOI:10.1021/jo00389a038

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