Journal of Organic Chemistry p. 2576 - 2580 (1987)
Update date:2022-08-04
Topics:
Keinan, Ehud
Perez, Daniel
A novel reducing system comprised of phenylsilane and catalytic amounts of Mo(CO)6 in refluxing THF efficiently effects conjugate reduction of Michael acceptors, including α,β-unsaturated ketones, carboxylic acids, carboxylic esters, amides, and nitriles.The process involves molybdenum-catalyzed hydrosilation, followed by hydrolysis of the intermediate silyl enol ether.Hydride is regioselectively transferred from the hydridosilane to the β-carbon of the substrate, and a proton from water is incorporated into the α-carbon.
View MoreContact:0792-8228321
Address:10TH Floor No.121 binjiang Road Xunyang District
Tianjin Crest Pharmaceutical R&D Co., Ltd. (Tianjin Yao Technology Development Co., Ltd.)(expird)
Contact:+86-22-66211386
Address:Building B5-405, No, 80 4th Avenue, TEDA, Tianjin, China P.R. 300457
Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd
website:http://www.jlpharms.com
Contact:+86-571-86982636
Address:Rm A606, Fuyi Center, jianqiao street, Jianggan Area
website:http://www.synchemie.com/
Contact:+86-574-87642758
Address:Room 901, Yinyi Bund Building, 132 Renmin Road
Contact:86-898-65311214
Address:Room 102, BLDG. 68 Jiangnan City, No. 66 Heping Road,Haikou, Hainan, China
Doi:10.1021/jo00388a034
(1987)Doi:10.1016/j.bmcl.2008.08.067
(2008)Doi:10.1016/j.tetasy.2008.08.022
(2008)Doi:10.1016/j.bmcl.2008.08.043
(2008)Doi:10.1002/anie.200802910
(2008)Doi:10.1039/b807869f
(2008)