One Step Synthesis of 5-Acylamino-2,2-dialkyl-4-oxo-1,3-dioxanes: A Cyclic System Enabling Simultaneous Protection of Hydroxyl and Carboxyl Functions in α-Hydroxymethyl-α-Amino Acids

Article abstract of DOI:10.1055/s-1986-31734

N-Acyl-α-alkylserines 1 were heated with aliphatic acetals 2 in the presence of mineral acid to afford 5-acylamino-2,2-dialkyl-4-oxo-1,3-dioxanes 3.This cyclic system is stable enough to survive amino group deprotection as well as peptide coupling conditi