
Inorganica Chimica Acta (2020)
Update date:2022-08-05
Topics:
Du, LongChao
Hu, Yang
Yang, Jie
A novel salen derivative, named as 6,6′-((1E,1′E)-(1,2-phenylenebis(azaneylylidene))bis(methaneylylidene))bis(4-(4-iodobutyl)-2-methylphenol) (PA), was obtained for the detection of Zn2+. PA exhibited highly sensitive and selective via a chelation mechanism, which was promoted by Zn2+, accompanied by enhanced fluorescence. After adding various metal ions in the PA solution, only Zn2+ caused PA fluorescence enhancement. Other cations (such as Ag+, Al3+, Ba2+, Ca2+, Cd2+, Cr3+, Cu2+, Fe3+, Hg2+, K+, La3+, Li+, Mg2+, Na+, Ni2+ and Pb2+) cannot induce similar response. The binding stoichiometry and detection limit was 1:1 and 16.3 nM, respectively, which is superior to the reported Zn2+ fluorescent probes based on salen derivatives. The binding process was reasonably speculated by fluorescence measurements, infrared spectroscopy, 1H NMR titrations, FT-IR, mass spectroscopy (MS) and density functional theory (DFT) calculation. In addition, PA can be used for Zn2+ fluorescence imaging in HeLa cells. This work indicated that this probe would be of great application prospect in medical diagnosis.
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(2021)