
Tetrahedron Letters p. 59 - 60 (1987)
Update date:2022-07-29
Topics:
Alami, N. E.
Belaud, C.
Villieras, J.
The organozinc reagent derived from ethyl α-(bromomethyl) acrylate is prepared at 17 deg C < T < 20 deg C (duplication < 10percent) and then coupled efficiently with nucleophilic imines to give α-methylene γ-lactames with high yields.
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