Journal of Medicinal Chemistry p. 1588 - 1595 (1987)
Update date:2022-09-26
Topics:
Manley, Paul W.
Allanson, Nigel M.
Booth, Robert F. G.
Buckle, Philip E.
Kuzniar, Edward J.
et al.
Analogues of 4-<<2-(1H-imidazol-1-yl)-1-<<(4-methoxyphenyl)methoxy>methyl>ethoxy>methyl>benzoic acid (5m) were prepared and evaluated as thromboxane synthase inhibitors.A series of esters of 5m showed a parabolic relationship between lipophilicity and inh
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