NOVEL SYNTHESES OF 1-SUBSTITUTED-7,8-DIALKOXYISOCHROMAN-3-ONES AND 8-SUBSTITUTED-2,3,9,10-TETRAMETHOXYBERBINES

Article abstract of DOI:10.1016/S0040-4020(01)87624-9

A novel and general method for the synthesis of 1-substituted-7,8-dialkoxyisochroman-3-ones is described from 3,4-dialkoxy-N,N-dimethylbenzylamines (5a-5b). 1-Methyl- and 1-phenyl-7,8-dimethoxyisochroman-3-ones (7g and 7d) have been used to synthesise 8-methyl- and 8-phenyl-tetrahydropalmatines (9a,10a and 9b, 10b).No synthesis of these compounds have been so far reported.