Phenacyl-Directed Alkylation of Imidazoles: A New Regiospecific Synthesis of 3-Substituted L-Histidines

DOI: 10.1021/jo00392a018

Source and publish data:

Journal of Organic Chemistry p. 3591 - 3594 (1987)

Update date:2022-09-26

Topics: Imidazoles Regiospecific Synthesis

Authors:

Chivikas, Cleo J.

Hodges, John C.

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Article abstract of DOI:10.1021/jo00392a018

A new strategy for regiospecific imidazole alkylation of suitably protected histidines is described wherein a phenacyl group serves as a protecting group of the distal imidazole nitrogen atom.Alkylation of N-BOC-1-phenacyl-L-histidine methyl ester at N(3)

Full text of DOI:10.1021/jo00392a018

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