Phenacyl-Directed Alkylation of Imidazoles: A New Regiospecific Synthesis of 3-Substituted L-Histidines

DOI: 10.1021/jo00392a018

Source and publish data:

Journal of Organic Chemistry p. 3591 - 3594 (1987)

Update date:2022-09-26

Topics: Imidazoles Regiospecific Synthesis

Authors:

Chivikas, Cleo J.

Hodges, John C.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00392a018

A new strategy for regiospecific imidazole alkylation of suitably protected histidines is described wherein a phenacyl group serves as a protecting group of the distal imidazole nitrogen atom.Alkylation of N-BOC-1-phenacyl-L-histidine methyl ester at N(3)

Full text of DOI:10.1021/jo00392a018

Products guided by the article

Product name:5-((S)-2-tert-Butoxycarbonylamino-2-methoxycarbonyl-ethyl)-1-(3,4-dimethoxy-benzyl)-3-(2-oxo-2-phenyl-ethyl)-3H-imidazol-1-ium; chloride

Cas No:109013-69-6

R&D Labs maybe for 109013-69-6

Dragon Chemical Co., Ltd.

Contact:0571-

Address:zhejing
Anhui Gusheng Import&Export CO.,LTD

Contact:86-551-63662296

Address:Jinzhai Road NO.162 ,hefei, china
Qingdao XinYongAn Chemicals Co., Ltd

Contact:+86-532-81107967

Address:Chengyang dual-port industrial park by the sea，Qingdao
Hangzhou Ledun Technology Co.,Ltd.

Contact:86-571-18767088918

Address:No.6 street,XiaSha,Hangzhou,China.
CHENGDU CHENLV HERB CO.,LTD

Contact:+86-28-88523492

Address:714rooms of Time Square, Pujiang County

Relevant to this article

Doi:10.1021/ja00250a036
(1987)
Mechanism of Intramolecular Photocycloadditions of Cyclooctenones

Doi:10.1021/jo00392a020
(1987)
Doi:10.1016/S0020-1693(00)83364-2
(1988)
A high performance oxidation method for secondary alcohols by inductive activation of TEMPO in combination with pyridine-bromine complexes

Doi:10.1016/j.tet.2008.08.051
(2008)
Cross-linked-polymer-supported N-{2'-[(Arylsulfonyl)amino][1,1'- binaphthalen]-2-yl}prolinamide as organocatalyst for the direct aldol intermolecular reaction under solvent-free conditions

Doi:10.1002/hlca.201200422
(2012)
Synthesis of E isomer and crystal structures of E and Z isomers of 3-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl)acrylonitrile

Doi:10.1007/s10870-007-9290-x
(2008)

Article Doi