Isozyme-Specific Enzyme Inhibitors. 14. 5'(R)-C-adenosine 5'-(β,γ-Imidotriphosphate), a Potent Inhibitor of Rat Methionine Adenosyltransferases

Article abstract of DOI:10.1021/jm00392a013

The title compound is a covalent adduct of L-methionine (Met) and β,γ-imido-ATP.In its synthesis the N-Boc derivative of 5'(R)-C-(aminomethyl)-N⁶-benzoyl-5'-O-tosyl-2',3'-O-isopropylideneadenosine was converted by the succesive actions of CF3CO