Isozyme-Specific Enzyme Inhibitors. 14. 5'(R)-C-adenosine 5'-(β,γ-Imidotriphosphate), a Potent Inhibitor of Rat Methionine Adenosyltransferases

DOI: 10.1021/jm00392a013

Source and publish data:

Journal of Medicinal Chemistry p. 1599 - 1603 (1987)

Update date:2022-09-26

Topics:

Authors:

Kappler, Francis

Vrudhula, Vivekananda M.

Hampton, Alexander

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00392a013

The title compound is a covalent adduct of L-methionine (Met) and β,γ-imido-ATP.In its synthesis the N-Boc derivative of 5'(R)-C-(aminomethyl)-N⁶-benzoyl-5'-O-tosyl-2',3'-O-isopropylideneadenosine was converted by the succesive actions of CF3CO

Full text of DOI:10.1021/jm00392a013

Products guided by the article

Product name:Toluene-4-sulfonic acid (R)-2-amino-1-[(3aR,4S,6R,6aR)-6-(6-benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-ethyl ester

Cas No:109087-25-4

R&D Labs maybe for 109087-25-4

Shanghai HengXun Pharmaceutical Tech. Co., Ltd.

Contact:86-86-52730756

Address:Room 603, No. 240, Tianmuzhong Road, Zhabei, Shanghai, China
Hangzhou Maytime Bio-Tech Co.,Ltd.

website:http://www.maytime.com.cn

Contact:+86-571-88925295 88920965

Address:NO.2-1701 Ganghui Central Ningwei Street, Xiaoshan Hangzhou Zhejiang China
zhejiang huangyan wanfeng pharm chem co.ltd

Contact:+86-576- 84160728

Address:No. 5 Dazha Road, Economic,Development Zone(JiangKou), Zhejiang, China
Suzhou ATL Chemical Co.,ltd

Contact:+86-0512-69209969

Address:Room 317,Lushan Road,Suzhou New District,Jiangsu Province,China.
Nanjing Norris Pharm Technology Co., Ltd.

Contact:+86-13901585132

Address:2 Qiande Road, Jiangning sciencepark Hi-Tech Zone, Nanjing, P.R.China

Relevant to this article

NOVEL DISTANNOXANE-CATALYZED TRANSESTERIFICATION AND A NEW ENTRY TO α,β-UNSATURATED CARBOXYLIC ACIDS

Doi:10.1016/S0040-4039(00)84535-9
(1986)
Syntheses and Chemistry of Some Dibenzazepines

Doi:10.1021/jo00380a010
(1987)
Development of catalytic asymmetric 1,4-addition and [3 + 2] cycloaddition reactions using chiral calcium complexes

Doi:10.1021/ja8032058
(2008)
Intramolecular Michael-type additions to vinyl bissulfoxides: Enantioselective synthesis of chiral aldehydes

Doi:10.1055/s-2008-1067176
(2008)
Synthesis of fluorinated purine and 1-deazapurine glycosides as potential inhibitors of adenosine deaminase

Doi:10.1021/jo102579g
(2011)
α,β-Methylene-2′-deoxynucleoside 5′-triphosphates as noncleavable substrates for DNA polymerases: Isolation, characterization, and stability studies of novel 2′-deoxycyclonucleosides, 3,5′-cyclo-dG, and 2,5′-cyclo-dT

Doi:10.1021/jm800692a
(2008)

Article Doi