Isozyme-Specific Enzyme Inhibitors. 14. 5'(R)-C-adenosine 5'-(β,γ-Imidotriphosphate), a Potent Inhibitor of Rat Methionine Adenosyltransferases

DOI: 10.1021/jm00392a013

Source and publish data:

Journal of Medicinal Chemistry p. 1599 - 1603 (1987)

Update date:2022-09-26

Topics:

Authors:

Kappler, Francis

Vrudhula, Vivekananda M.

Hampton, Alexander

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Article abstract of DOI:10.1021/jm00392a013

The title compound is a covalent adduct of L-methionine (Met) and β,γ-imido-ATP.In its synthesis the N-Boc derivative of 5'(R)-C-(aminomethyl)-N⁶-benzoyl-5'-O-tosyl-2',3'-O-isopropylideneadenosine was converted by the succesive actions of CF3CO

Full text of DOI:10.1021/jm00392a013

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