Isozyme-Specific Enzyme Inhibitors. 14. 5'(R)-C-adenosine 5'-(β,γ-Imidotriphosphate), a Potent Inhibitor of Rat Methionine Adenosyltransferases

DOI: 10.1021/jm00392a013

Source and publish data:

Journal of Medicinal Chemistry p. 1599 - 1603 (1987)

Update date:2022-09-26

Topics:

Authors:

Kappler, Francis

Vrudhula, Vivekananda M.

Hampton, Alexander

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00392a013

The title compound is a covalent adduct of L-methionine (Met) and β,γ-imido-ATP.In its synthesis the N-Boc derivative of 5'(R)-C-(aminomethyl)-N⁶-benzoyl-5'-O-tosyl-2',3'-O-isopropylideneadenosine was converted by the succesive actions of CF3CO

Full text of DOI:10.1021/jm00392a013

Products guided by the article

Product name:Toluene-4-sulfonic acid (R)-2-amino-1-[(3aR,4S,6R,6aR)-6-(6-benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-ethyl ester

Cas No:109087-25-4

R&D Labs maybe for 109087-25-4

Zhejiang Kaili Industrial Co., Ltd

Contact:+86-571-85241926

Address:lantian business center,No.18 Moganshan Road
Advanced Biotech

Contact:+1-973-357-0577

Address:10 Taft Rd.
ChengduChroma-BiotechCo.,Ltd.

Contact:86-28-61993785

Address:No.70-13-21, North Section, Erhuan
Tai zhou world Pharm & Chem Co., Ltd

Contact:+86-576-85301198

Address:Rome 1001,wangjiang plaza,unti 2,jinshan east Road linhai,zhejiang,china
Nanjing HuiBaiShi Biotechnology Co.,Ltd.

Contact:+86 (25)58745219

Address:No.606 Ningliu Road,LiuHe District.

Relevant to this article

NOVEL DISTANNOXANE-CATALYZED TRANSESTERIFICATION AND A NEW ENTRY TO α,β-UNSATURATED CARBOXYLIC ACIDS

Doi:10.1016/S0040-4039(00)84535-9
(1986)
Syntheses and Chemistry of Some Dibenzazepines

Doi:10.1021/jo00380a010
(1987)
Development of catalytic asymmetric 1,4-addition and [3 + 2] cycloaddition reactions using chiral calcium complexes

Doi:10.1021/ja8032058
(2008)
Intramolecular Michael-type additions to vinyl bissulfoxides: Enantioselective synthesis of chiral aldehydes

Doi:10.1055/s-2008-1067176
(2008)
Synthesis of fluorinated purine and 1-deazapurine glycosides as potential inhibitors of adenosine deaminase

Doi:10.1021/jo102579g
(2011)
α,β-Methylene-2′-deoxynucleoside 5′-triphosphates as noncleavable substrates for DNA polymerases: Isolation, characterization, and stability studies of novel 2′-deoxycyclonucleosides, 3,5′-cyclo-dG, and 2,5′-cyclo-dT

Doi:10.1021/jm800692a
(2008)

Article Doi