Regioselective O-sulfonylation of N,N-bis(2-hydroxyalkyl)tosylamides as a synthetic key step to enantiopure morpholines

DOI: 10.1021/acs.orglett.6b03342

Source and publish data:

Organic Letters p. 70 - 73 (2017)

Update date:2022-08-04

Topics:

Authors:

Foschi, Francesca

Albanese, Domenico

Pecnikaj, Ilir

Tagliabue, Aaron

Penso, Michele

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Article abstract of DOI:10.1021/acs.orglett.6b03342

The synthesis of enantiopure 2,6-disubstituted morpholines was realized through sequential ring opening of two different optically pure oxiranes by a tosylamide, under solid-liquid phase-transfer catalysis (SL-PTC) conditions, mono-O-sulfonylation of the

Full text of DOI:10.1021/acs.orglett.6b03342

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