CONVENIENT TWO-STEP STEREOSPECIFIC HYDROXY-SUBSTITUTION WITH RETENTION IN β-HYDROXY-δ-LACTONES. 4(R)-HETEROSUBSTITUTED MEVINOLIN AND -ANALOGS

DOI: 10.1016/S0040-4039(00)85044-3

Source and publish data:

Tetrahedron Letters p. 4709 - 4712 (1986)

Update date:2022-08-03

Topics:

Authors:

Bartmann, W.

Beck, G.

Granzer, E.

Jendralla, H.

Kerekjarto, B. v.

Wess, G.

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Article abstract of DOI:10.1016/S0040-4039(00)85044-3

Michael additions of mercaptanes and amines to optically pure 6-alkyl-5,6-dihydro-2H-pyran-2-ones of the mevinolin type <6(R)>-5 and the aromatic analog <6(S)>-7 are stereospecific to give 4(R)-substituted mevinolin analogs.

Full text of DOI:10.1016/S0040-4039(00)85044-3

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