CONVENIENT TWO-STEP STEREOSPECIFIC HYDROXY-SUBSTITUTION WITH RETENTION IN β-HYDROXY-δ-LACTONES. 4(R)-HETEROSUBSTITUTED MEVINOLIN AND -ANALOGS

DOI: 10.1016/S0040-4039(00)85044-3

Source and publish data:

Tetrahedron Letters p. 4709 - 4712 (1986)

Update date:2022-08-03

Topics:

Authors:

Bartmann, W.

Beck, G.

Granzer, E.

Jendralla, H.

Kerekjarto, B. v.

Wess, G.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)85044-3

Michael additions of mercaptanes and amines to optically pure 6-alkyl-5,6-dihydro-2H-pyran-2-ones of the mevinolin type <6(R)>-5 and the aromatic analog <6(S)>-7 are stereospecific to give 4(R)-substituted mevinolin analogs.

Full text of DOI:10.1016/S0040-4039(00)85044-3

Products guided by the article

Product name:(S)-6-{2-[3-(4-Fluoro-phenoxy)-propyl]-4,6-dimethyl-phenoxymethyl}-5,6-dihydro-pyran-2-one

Cas No:109273-99-6

R&D Labs maybe for 109273-99-6

Chemsigma International Co.,Ltd.

website:http://www.chemsigma.com

Contact:86-025-58748998

Address:Rm.705, 15th Building,Rd.Xinke II
Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

Contact:--

Address:Huadian Pioneer Park, Huadian Township, Qihe County, Dezhou City, Shandong, P.R.China
N&R INDUSTRIES,INC

Contact:Tel:+86-29-88764861 Fax:+86-29-88764861

Address:Rm#2107, Block A, Epin Meidao Building, Gaoxin Rd, Hi-Tech Zone, Xi’an, China
Suzhou Health Chemicals Co., Ltd.

website:http://www.healthchems.com

Contact:13776257979

Address:No. 338, Jingang Avenue,
Brichem ( Haikou ) Co. Ltd.

Contact:86-898-65311214

Address:Room 102, BLDG. 68 Jiangnan City, No. 66 Heping Road,Haikou, Hainan, China

Relevant to this article

A novel method for the synthesis of thioacetates using benzyltriethyl- ammonium tetrathiomolybdate and acetic anhydride

Doi:10.1055/s-0028-1083517
(2008)
Chroman-3-amides as potent Rho kinase inhibitors

Doi:10.1016/j.bmcl.2008.10.080
(2008)
Synthesis and structure-activity relationships of pyridinyl-1 H -1,2,3-triazolyldihydroisoxazoles as potent inhibitors of tubulin polymerization

Doi:10.1016/j.ejmech.2014.11.063
(2015)
Visible-Light Photoredox Catalysis: Direct Synthesis of Sulfonated Oxindoles from N-Arylacrylamides and Arylsulfinic Acids by Means of a Cascade C-S/C-C Formation Process

Doi:10.1002/asia.201500498
(2015)
Novel high-affinity and selective biaromatic 4-substituted γ-hydroxybutyric acid (GHB) analogues as GHB ligands: Design, synthesis, and binding studies

Doi:10.1021/jm801112u
(2008)
Synthesis and SAR development of novel P2X₇ receptor antagonists for the treatment of pain: Part 1

Doi:10.1016/j.bmcl.2011.04.034
(2011)

Article Doi