Synthesis and evaluation of melphalan-containing N,N-dialkylenkephalin analogues as irreversible antagonists of the δ opioid receptor

Article abstract of DOI:10.1021/jm00392a025

N,N-Dialkylated leucine enkephalin analogues containing melphalan (Mel) in place of Phe⁴ were synthesized as potentially irreversible antagonists of the δ opioid receptor. These compounds, along with the corresponding Phe⁴ peptides,