Tetrahedron p. 4217 - 4220 (1987)
Update date:2022-08-05
Topics: Synthesis Efficient Enzymatic Synthesis Experimental Moiety Penicillins
Baldwin, Jack E.
Adlington, Robert M.
Crabbe, M. James C.
Nomoto, Takashi
Schofield, Christopher J.
meta-Carboxyphenylacetyl-L-cysteinyl-D-valine was shown to be a highly efficient substrate for Isopenicillin N Synthetase, with similar Michaelis constant and maximum velocity parameters to the natural substrate δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine.
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