AN EFFICIENT SUBSTITUTE FOR THE α-AMINODIPOYL MOIETY OF δ-(L-α-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE IN THE ENZYMATIC SYNTHESIS OF PENICILLINS

Article abstract of DOI:10.1016/S0040-4020(01)83463-3

meta-Carboxyphenylacetyl-L-cysteinyl-D-valine was shown to be a highly efficient substrate for Isopenicillin N Synthetase, with similar Michaelis constant and maximum velocity parameters to the natural substrate δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine.