Structure-activity relationships among analogues of pemedolac, cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]indole-1- cetic acid, a potent analgesic agent

DOI: 10.1021/jm00119a024

Source and publish data:

Journal of Medicinal Chemistry p. 2211 - 2217 (1988)

Update date:2022-09-26

Topics:

Authors:

Mobilio Mobilio

Humber Humber

Katz Katz

Demerson

Hughes Hughes

Brigance

Conway Conway

Shah Shah

Williams

Labbadia

De Lange

Asselin Asselin

Schmid Schmid

Newburger

Jensen Jensen

Weichman

Chau Chau

Neuman Neuman

Wood Wood

et al. et al.

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Article abstract of DOI:10.1021/jm00119a024

The syntheses of analogues of pemedolac (cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]indole-1 acetic acid), a potent analgesic, are described. They were tested for analgesic and antiinflammatory effects in vivo and for inhibition of prosta

Full text of DOI:10.1021/jm00119a024

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