Tetrahedron Letters p. 675 - 680 (2018)
Update date:2022-08-04
Topics:
Chaisan, Nattawadee
Kaewsri, Wilailak
Thongsornkleeb, Charnsak
Tummatorn, Jumreang
Ruchirawat, Somsak
An efficient synthesis of N-acetyl-2-substituted indole derivatives via direct intramolecular hydroamination of N-acetyl-2-alkynylaniline derivatives was developed. The reaction could be applied to a wide range of substrates employing only 1–2 mol% of PtCl4 as the catalyst to furnish the desired indole products in moderate to excellent yields. The current protocol is efficient, reliable and scalable, and could serve as an important tool for convenient and rapid access to this important class of N-heterocyclic skeleton from readily available substrates.
View MoreContact:+86-25-85281586
Address:13F,Bld2#,South of Longpan Road
QINGDAO NEW FLOURISH INTERNATIOANAL TRADE CO., LTD.
Contact:+86 532 80861829
Address:No. 1, Yinchuan East Road, 266061, Qingdao, China
Chengdu King-tiger Pharm-chem. Tech. Co., Ltd
Contact:028-85317716
Address:Tianfu Life Science Park, No. 88 South Keyuan Road, Gaoxin District, Chengdu City, Sichuan Province, PRC.
Guilin Zhenda Bio-Tech Co., Ltd.
Contact:86-773-3568977
Address:-Yangtang shangshui industry park, Lingui county,
Penglai Qianwei Chemical Co., Ltd.
Contact:86-535-3357802
Address:Shahelu (north), Penglai, Shandong, China
Doi:10.1016/j.bmc.2008.10.034
(2008)Doi:10.1002/jhet.5570240103
(1987)Doi:10.1016/S0040-4020(01)87538-4
(1986)Doi:10.1021/ja201088k
(2011)Doi:10.1021/jo00229a047
(1987)Doi:10.1002/hlca.19920750209
(1992)