European Journal of Medicinal Chemistry p. 267 - 275 (1992)
Update date:2022-09-26
Topics:
Blanc, M
Cussac, M
Boucherle, A
Leclerc, G
Functionallized 2-thiohydantoins were synthesized.Their immunomodulating and anticancer actions were evaluated.It is shown that for these potentially active products on chronic inflammatory diseases involving cellular-mediated immunity the development of immunomodulating activityis related to the cyclised thiourea structure.Anticancer activity is weak.These biological activities are however insufficient to promote an industrial development. 2-thiohydantoins / immunomodulators / anticancer agents
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