Fluoro carbocyclic nucleosides: Synthesis and antiviral activity of 2'- and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-methyluracil and carbocyclic 1-(2-deoxy-2-fluoro-β-D-arabinofuranosy

DOI: 10.1021/jm00163a030

Source and publish data:

Journal of Medicinal Chemistry p. 179 - 186 (1990)

Update date:2022-08-04

Topics: Synthesis Pyrimidine Nucleosides Antiviral Activity Antiviral Experimental Carbocyclic Fluoro

Authors:

Borthwick

Evans Evans

Kirk Kirk

Biggadike

Exall Exall

Youds Youds

Roberts Roberts

Knight Knight

Coates Coates

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Article abstract of DOI:10.1021/jm00163a030

The racemic carbocyclic 2'-fluoroarabinosyl pyrimidine nucleosides 8, 9 (C-FIAU), 12, and 13 (C-FMAU) and the 2'-fluororibosyl pyrimidine nucleosides 17, 20, and 21 were prepared from their respective protected 2'-fluoro amino diols 5 and 14. The carbocyc

Full text of DOI:10.1021/jm00163a030

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