
Tetrahedron Letters p. 83 - 86 (1987)
Update date:2022-08-05
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Hatanaka, Minoru
The chiral key intermediate of 1β-methylcarbapenem antibiotic is synthesized via (2R,3R,4S,5R)-3-amino-2,5-dimethyl-5-pentanolide-4-carboxylic acid, which is prepared in a stereoselective manner from (R)-(-)-hydroxy-butyrate.
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(1988)